Niumag has developed a low cost MRI suitable for small animal veterinary diagnosis (e.g. tumor, lung disease, tendon damage, etc), for placing in animal hospitals

Preclinical live animal physiology and pathology research

Small animal models of human diseases constitute a major step for evaluation of new therapies. Preclinical imaging provides quantitative data, allowing in vivo studies of therapy strategies.

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Untouched visceral anatomy

MRI is a non-invasive technique suitable to image soft tissues like muscle, brain and other organs. With this technique being available for humans, it should therefore also be suitable to image other or-ganisms.

Tumor Research

Non-invasive MRI tumor imaging shows high resolutions between normal tissues to tumors which provide a method to detect the tumorigenesis and monitor the tumor development rate

Diabetes and obesity research

Whole Body Composition Analyzer based on TD-NMR provides a precise method for measurement of Lean Tissue, Fat, and Fluid in live mice and rats. As a powerful, non-destructive and non-invasive tool for characterizing, screening and phenotyping mouse models in research laboratories, It has become the industrial standard for fat and lean measurement in live mice with installations in major diabetes and obesity research institutes and universities. The key feature is:that longitudinal studies become possible, because the animal is carefully handled without anesthesia.

Graft rejection detection in organ transplants

Organ transplants are a commonly accepted therapeutic modality for treatment of endstage patients. However, long-term graft survival is still threatened by acute and chronic rejection, as well as by complications such as infection caused by immunosuppression. Thus, a proper evaluation of the progression of graft rejection could have a significant impact on the management and outcome of transplant patients. Although numerous techniques have been used for the detection of organ allograft rejection, development of special, sensitive, and non-invasive methods for the diagnosis of rejection is still a major challenge. Biopsy is generally accepted as the “gold standard” for diagnosing graft rejection. However, this procedure is not only prone to sampling errors, but it also exposes patients to the risks of possible bleeding and infection.

Small animal nutrition

Dietary analysis finds out how food affects the body composition. MRI is a promising technology in that it can provide non-invasive imaging with sub-millimeter resolution and high tissue contrast. This has been applied to the imaging and relaxation analysis of ex vivo and in vivo research on various compounds (such as cholesterol, fat, protein, etc) taken in diets.

Pharmaceutical field

During the last years, NMR spectroscopy and NMR imaging (MRI) have been increasingly used to study drug effects in vitro and in vivo. However, high installation and running costs of the commonly used superconducting magnet technology limits the application range and prevents the further spread of this non-invasive technology. NIUMAG productions use permanent magnets and is much less cost intensive.

Non-invasive monitoring of drug delivery processes

The usefulness and capabilities of MRI are generally well appreci-ated in the drug delivery community. The majority of the in vitro ap-plications of MRI are linked to the monitoring of the hydration, swelling and erosion of matrix tablets. Preclinical in vivo applica-tions of MRI on mice and rats include studies of the fate of biode-gradable polymers, liposomes, mucoadhesive polymers and cells.

Preclinical live animal drug discovery and toxicity ( such as Diabetes drug effect and toxicity)

The process to discover and to bring a drug to market is complex, costly and long, requiring in average 12 years. It is expected that im-provements in the chemistry should reduce the attrition rate, thus in-creasing the success rate and, perhaps, reducing the development costs at the same time. A much better understanding of this perform-ance relationship is needed to develop predictive algorithms that will increase the survival rate of compounds in clinical trials. The devel-opment of imaging strategies meets the requirements.

Specifications AniMR-150

• Magnet: permanent magnet 0.25T
• Magnetic field intensity: 0.25 T / Stray magnetic field: 50mT
• Magnetic field stability: 8 hours = < 150ppm VRMS / 10 min = < 5ppm VRMS
• Polar distance: 264 mm.
• Uniform field gap: 210mm
• Diameter of poles: 590 mm.
• RF: radio frequency pulse frequency range of 1MHz-49.9MHz
• Magnet temperature control: dual system of non.linear precise temperature control, chamber temperature control accuracy of 0.05ºC
• RF Power Amplifier: Peak output power more than 125W, the linear distortion is less than 0.5%
• RF frequency control accuracy: 0.01Hz
• Signal sending and receiving mode: digital quadrature detection
• Receiver gain more than 40dB, the maximum bandwidth of more than 300KHz<(li>
• X, Y, Z three directions peak gradient intensity greater than 1.5 Gauss/cm
• Large diameter probe coil: 150mm sample coil
• Effective sample detection range 150mm * 150mm * 150mm
• 150mm standard sample image quality, image linearity (x, y, z three direction) greater than 90%
• Cspatial resolution better than 2 mm
• Based on PCI bus industrial control computer platform, dual-core CPU, 2G DDR memory, 250G hard disk, DVD_R/W CD-ROM.

Other fields

such as immunology, development, endocrinology, etc.

Images of the AniMR 150

For prices or addional information of the MRI Spectrometer, model AniMR, from Niumag, please call us at
+34 91 355 58 03 or send us an e-mail to :